张龙龙

发布者:张毅发布时间:2024-07-09浏览次数:109




职务:特聘研究员

邮箱: zhangll@qufudan.com

项目名称:胆固醇类似物脂质纳米粒mRNA核酸疫苗淋巴靶向递送

研究领域:mRNA LNP、脂质体、纳米粒等纳米递送系统给药

项目 1:胆固醇类似物脂质纳米粒mRNA核酸疫苗淋巴靶向递送(阶段:配方工艺优化)

项目 2:新型补铁剂铁-碳水化合物纳米药物开发(阶段:立项)


教育经历

博士,药学院,复旦大学,2017.09-2021.06

硕士,药学院,山东大学,2012.09-2015.06

本科,药学院,山东大学,山东大学,

工作经历

博士后,药学院,清华大学,2022.10-2024.10

高级研究员,ADC,君盟生物,2022.01-2022.08

高级研究员,CMC,斯微生物,2021.07-2021.12

制剂研究员,复杂制剂,蓝贝望生物,2016.07-2017.07

制剂研究员,仿制药研究所,恒瑞医药,2015.07-2016.06

 

研究领域

mRNA LNP or LPP 递送,纳米药物递送系统,复杂制剂仿制药


出版物与专利

1.Li Y, Zhang M, Li S, Zhang L, Kim J, Qiu Q, et al. Selective ischemic-hemisphere targeting Ginkgolide B liposomes with improved solubility and therapeutic efficacy for cerebral ischemia-reperfusion injury. Asian Journal of Pharmaceutical Sciences, 2023, 18(2): 100783-100801.

2.Zhang L, Zhu Y, Wei X, Chen X, Li Y, Zhu Y, et al. Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model. Acta Pharmaceutica Sinica B, 2022, 12(8): 3427-3447.

3.Xia J, Ma S, Zhu X, Chen C, Zhang R, Cao Z, Zhang L, Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science advances 2022, 8(6): 1262-1281.

4.Chen X, Ling X, Xia J, Zhu Y, Zhang L, He Y, et al. Mature dendritic cell-derived dendrosomes swallow oxaliplatin-loaded nanoparticles to boost immunogenic chemotherapy and tumor antigen-specific immunotherapy. Bioactive Materials, 2022, 15: 15-28.

5.Wang, H.; Zhu, Y.; Zhang, L.; Liu, H.; Liu, C.; Zhang, B. et al. Nanoplateletsomes for rapid hemostasis performance. Chinese Chemical Letters, 2022, 33, 2937-2941.

6.Zhang M, Ren H, Li K, Xie S, Zhang R, Zhang L, et al. Therapeutic effect of various ginsenosides on rheumatoid arthritis. BMC Complementary Medicine and Therapies 2021, 21(1): 1-12

7.Zhang L, Zhang P, Zhao Q, Zhang Y, Cao L, Luan Y. Doxorubicin-loaded polypeptide nanorods based on electrostatic interactions for cancer therapy. Journal of colloid and interface science 2016, 464: 126-136.

8.Zhang L, Liu J, Tian T, Gao Y, Ji X, Li Z, et al. Pharmaceutically active ionic liquid self-assembled vesicles for the application as an efficient drug delivery system. Chemphyschem 2013, 14(15): 3454-3457.