姓名：王建新
职称：教授
电子邮件：jxwang@shmu.edu.cn
电话：021-51980002
学历：博士
个人简历
1971年8月出生，1999年毕业于华西医科大学药学院药剂学专业，获博士学位。同年7月进入上海市中药研究所工作，2001年12月任高级工程师。
2001年7月至2005年4月曾任上海市中药研究所常务副所长，2005年5月作为复旦大学引进人才进校工作。
2009年7月至2010年8月于美国密西根大学药学院做访问学者。
2007年6月至2013年1月担任复旦大学药学院药剂学教研室主任。
2012年12月至2021年8月任复旦大学药学院副院长。
2021年9月至今任复旦大学药学院党委书记。
现任衢州复旦研究院院长。
社会任职
国家药品注册审评专家咨询委员会委员
国家中药品种保护审评专家
“克服递药屏障高端制剂”全国重点实验室副主任
复旦大学中西医结合研究院药物研究所所长
复杂药物制剂联合研究中心（复旦大学-则正药业）主任
研究成果
主持国家重大新药创制专项、国家自然科学基金等国家及省部级研究课题30余项，在Science Advances、ACS Nano、Nano-Micro Letters、Journal of Controlled Release等国内外杂志发表学术论文220余篇，其中SCI论文120余篇；主编《药剂学》、《生物药剂学与药物动力学》等规划教材或专著4部，副主编教材或专著6部，上海市精品课程《药物动力学》负责人。完成了30余项企业合作项目的研究开发，获新药证书或临床批件16项，获授权发明专利20余项。
上海市精品课程《药物动力学》负责人，复旦大学《生物药剂学与药物动力学》课程首席教师。
教材与专著
1.《生物药剂学与药物动力学》主编，中国医药科技出版社，2021年7月出版
2.《药剂学》副主编，高等教育出版社，2021年4月出版
3.《现代中药制剂设计》主编，中国医药科技出版社，2020年6月出版
4.《生物药剂学与药物动力学》主编，中国医药科技出版社，2016年1月出版
5.《药剂学》主编，人民卫生出版社，2015年4月出版
6.《药剂学》副主编，高等教育出版社，2014年3月出版
7.《现代药物动力学》副主编，人民卫生出版社，2011年12月出版
8.《现代中药制剂设计理论与实践》副主编，人民卫生出版社，2010年5月出版
9.《图解药剂学》副主编，人民卫生出版社，2008年12月出版
社会兼职
中国药学会药剂专业委员会副主任委员
世界中医药学会联合会中药新型给药系统专业委员会副会长兼秘书长
中国民族医药学会经皮治疗分会副会长
中国药学会工业药剂学专业委员会委员
中国生物医学工程学会纳米医学与工程分会委员
中华民族团结进步协会中华传统医药委员会委员
上海市药学会药剂专委会副主任委员
上海市中医药学会中药分会副主任委员
《Pharmaceutical Fronts》副主编，《Pharmaceutical Science Advances》副主编
《国际药学研究》、《中国医药工业杂志》、《中成药》等杂志编委
研究方向
1. 基于疾病病理特征的靶向给药系统研究
2. 口服给药系统设计及吸收机制研究
3. 中药新型给药系统研究
4. 药物新制剂新剂型研究开发
代表性论著
1. Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu* and Jianxin Wang*. Ginsenoside Rg3 Endows Liposomes with Prolonged Blood Circulation and Reduced Accelerated Blood Clearance. Journal of Controlled Release, 2023, 364, pp. 23-36.
2. Shiyi Li, Ru Zhang, Anni Wang, Yang Li, Miaomiao Zhang, Jisu Kim, Ying Zhu, Qizheng Wang, Yue Zhang, Ying Wei* and Jianxin Wang*. Panax Notoginseng: Derived Exosome-Like Nanoparticles Attenuate Ischemia Reperfusion Injury Via Altering Microglia Polarization. Journal of Nanobiotechnology, 2023, 21(1), p. 416.
3. Jisu Kim, Ying Zhu, Sunhui Chen, Dongdong Wang, Shuya Zhang, Jiaxuan Xia, Shiyi Li, Qiujun Qiu, Hyukjin Lee and Jianxin Wang*. Anti-Glioma Effect of Ginseng-Derived Exosomes-Like Nanoparticles by Active Blood–Brain-Barrier Penetration and Tumor Microenvironment Modulation. Journal of Nanobiotechnology, 2023, 21(1), p. 253.
4. Qiujun Qiu, Sunhui Chen, Huining He, Jixiang Chen, Xinyi Ding, Dongdong Wang, Jiangang Yang, Pengcheng Guo, Yang Li, Jisu Kim, Jianyong Sheng, Chao Gao, Bo Yin, Shihao Zheng and Jianxin Wang*. An Injectable Signal-Amplifying Device Elicits a Specific Immune Response Against Malignant Glioblastoma. Acta Pharmaceutica Sinica B, 2023, 13(12), pp. 5091-5106.
5. Qiujun Qiu, Xinyi Ding, Jixiang Chen, Sunhui Chen and Jianxin Wang. Nanobiotechnology-Based Treatment Strategies for Malignant Relapsed Glioma. Journal of Controlled Release, 2023, 358, pp. 681-705.
6. Yang Li, Miaomiao Zhang, Shiyi Li, Longlong Zhang, Jisu Kim, Qiujun Qiu, Weigen Lu* and Jianxin Wang*. Selective Ischemic-Hemisphere Targeting Ginkgolide B Liposomes with Improved Solubility and Therapeutic Efficacy for Cerebral Ischemia-Reperfusion Injury, Asian Journal of Pharmaceutical Sciences, 2023, 18(2), p. 100783.
7. Ying Zhu, Anni Wang, Shuya Zhang, Jisu Kim, Jiaxuan Xia, Fengxue Zhang, Dan Wang, Qi Wang* and Jianxin Wang*. Paclitaxel-Loaded Ginsenoside Rg3 Liposomes for Drug-Resistant Cancer Therapy by Dual Targeting of the Tumor Microenvironment and Cancer Cells. Journal of Advanced Research, 2023, 49, pp. 159-173.
8. Sunhui Chen, Qiujun Qiu, Dongdong Wang, Dejun She, Bo Yin, Guolong Gu, Meihong Chai, Dong Nyoung Heo, Huining He* and Jianxin Wang*. Dual-Sensitive Drug-Loaded Hydrogel System for Local Inhibition of Post-Surgical Glioma Recurrence. Journal of Controlled Release, 2022, 349, pp. 565-579.
9. Jiaxuan Xia, Shaojie Ma, Xi Zhu, Chen Chen, Ru Zhang, Zhonglian Cao, Xing Chen, Longlong Zhang, Ying Zhu, Shuya Zhang, Shiyi Li, Guolong Gu, Xunbin Wei, Kunqian Yu and Jianxin Wang*. Versatile Ginsenoside Rg3 Liposomes Inhibit Tumor Metastasis by Capturing Circulating Tumor Cells and Destroying Metastatic Niches. Science Advances, 8(6), p. eabj1262.
10. Longlong Zhang, Yuefei Zhu, Xunbin Wei, Xing Chen, Yang Li, Ying Zhu, Jiaxuan Xia, Yiheng Huang, Yongzhuo Huang, Jianxin Wang* and Zhiqing Pang*. Nanoplateletsomes Restrain Metastatic Tumor Formation through Decoy and Active Targeting in a Preclinical Mouse Model, Acta Pharmaceutica Sinica B, 2022, 12(8), pp. 3427-3447.
11. Xing Chen, Xiang Ling, Jiaxuan Xia, Ying Zhu, Longlong Zhang, Yuwei He, Anni Wang, Guolong Gu, Bo Yin* and Jianxin Wang*. Mature Dendritic Cell-Derived Dendrosomes Swallow Oxaliplatin-Loaded Nanoparticles to Boost Immunogenic Chemotherapy and Tumor Antigen-Specific Immunotherapy. Bioactive Materials, 2022, 15, pp. 15-28.
12. Guolong Gu, Chen Chen, Shichao Zhang, Bo Yin* and Jianxin Wang*. Self-Assembly Dual-Responsive No Donor Nanoparticles for Effective Cancer Therapy. ACS Applied Materials & Interfaces, 2021, 13(43), pp. 50682-50694.
13. Ying Zhu, Jianming Liang, Caifang Gao, Anni Wang, Jiaxuan Xia, Chao Hong, Zhirong Zhong, Zhong Zuo, Jisu Kim, Hongwei Ren, Shiyi Li, Qi Wang, Fengxue Zhang* and Jianxin Wang*. Multifunctional Ginsenoside Rg3-Based Liposomes for Glioma Targeting Therapy. Journal of Controlled Release, 2021, 330, pp. 641-657.
14. Chao Hong, Jianming Liang, Jiaxuan Xia, Ying Zhu, Yizhen Guo, Anni Wang, Chunyi Lu, Hongwei Ren, Chen Chen, Shiyi Li, Dan Wang, Huaxing Zhan and Jianxin Wang*. One Stone Four Birds: A Novel Liposomal Delivery System Multi-Functionalized with Ginsenoside Rh2 for Tumor Targeting Therapy. Nano-Micro Letters, 2020, 12(1), p. 129.
15. Jianming Liang, Ying Zhu, Caifang Gao, Chengli Ling, Jing Qin, Qi Wang, Yongzhuo Huang, Weigen Lu* and Jianxin Wang*. Menthol-Modified Bsa Nanoparticles for Glioma Targeting Therapy Using an Energy Restriction Strategy. NPG Asia Materials, 2019, 11(1), p. 38.
16. Jia Hou, Xu Yang, Shiyi Li, Zhekang Cheng, Yuhua Wang, Jing Zhao, Chun Zhang, Yongji Li, Man Luo, Hongwei Ren, Jianming Liang, Jue Wang, Jianxin Wang* and Jing Qin*. Accessing Neuroinflammation Sites: Monocyte/ Neutrophil- Mediated Drug Delivery for Cerebral Ischemia. Science Advances, 5(7), p. eaau8301.
17. Caifang Gao, Jianming Liang, Ying Zhu, Chengli Ling, Zhekang Cheng, Ruixiang Li, Jing Qin, Weigen Lu* and Jianxin Wang*. Menthol-Modified Casein Nanoparticles Loading 10-Hydroxycamptothecin for Glioma Targeting Therapy. ACTA Pharmaceutica Sinica B, 2019, 9(4), pp. 843-857.
18. Hongwei Ren, Yuwei He, Jianming Liang, Zhekang Cheng, Meng Zhang, Ying Zhu, Chao Hong, Jing Qin, Xinchun Xu* and Jianxin Wang*. Role of Liposome Size, Surface Charge, and Pegylation On Rheumatoid Arthritis Targeting Therapy. ACS Applied Materials & Interfaces, 2019, 11(22), pp. 20304-20315.
19. Chao Hong, Dan Wang, Jianming Liang, Yizhen Guo, Ying Zhu, Jiaxuan Xia, Jing Qin, Huaxing Zhan and Jianxin Wang*. Novel Ginsenoside-Based Multifunctional Liposomal Delivery System for Combination Therapy of Gastric Cancer. Theranostics, 2019, 9(15), pp. 4437-4449.
20. Yuwei He, Ruixiang Li, Haichun Li, Shuya Zhang, Wentao Dai, Qian Wu, Lixian Jiang, Zicong Zheng, Shun Shen, Xing Chen, Yuefei Zhu, Jianxin Wang* and Zhiqing Pang*. Erythroliposomes: Integrated Hybrid Nanovesicles Composed of Erythrocyte Membranes and Artificial Lipid Membranes for Pore-Forming Toxin Clearance. ACS NANO, 2019, 13(4), pp. 4148-4159.
21. Ruixiang Li, Yuwei He, Ying Zhu, Lixian Jiang, Shuya Zhang, Jing Qin, Qian Wu, Wentao Dai, Shun Shen, Zhiqing Pang* and Jianxin Wang*. Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles. Nano Letters, 2019, 19(1), pp. 124-134.
22. Jianming Liang, Caifang Gao, Ying Zhu, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Jue Wang, Weigen Lu* and Jianxin Wang*. Natural Brain Penetration Enhancer-Modified Albumin Nanoparticles for Glioma Targeting Delivery. ACS Applied Materials & Interfaces, 2018, 10(36), pp. 30201-30213.
23. Jianming Liang, Ruixiang Li, Yuwei He, Chengli Ling, Qi Wang, Yongzhuo Huang, Jing Qin, Weigen Lu* and Jianxin Wang*. A Novel Tumor-Targeting Treatment Strategy Uses Energy Restriction Via Co-Delivery of Albendazole and Nanosilver. Nano Research, 2018, 11(9), pp. 4507-4523.
24. Ruixiang Li, Jianming Liang, Yuwei He, Jing Qin, Huining He, Seungjin Lee, Zhiqing Pang* and Jianxin Wang*. Sustained Release of Immunosuppressant by Nanoparticle-Anchoring Hydrogel Scaffold Improved the Survival of Transplanted Stem Cells and Tissue Regeneration. Theranostics, 2018, 8(4), pp. 878-893.
25. Ruixiang Li, Yuwei He, Shuya Zhang, Jing Qin and Jianxin Wang*. Cell Membrane-Based Nanoparticles: A New Biomimetic Platform for Tumor Diagnosis and Treatment. Acta Pharmaceutica Sinica B, 2018, 8(1), pp. 14-22.
26. Yuwei He, Ruixiang Li, Jianming Liang, Ying Zhu, Shuya Zhang, Zicong Zheng, Jing Qin, Zhiqing Pang* and Jianxin Wang*. Drug Targeting through Platelet Membrane-Coated Nanoparticles for the Treatment of Rheumatoid Arthritis. Nano Research, 2018, 11(11), pp. 6086-6101.
27. Yisi Tang, Jianming Liang, Aihua Wu, Yingzhi Chen, Pengfei Zhao, Tingting Lin, Meng Zhang, Qin Xu, Jianxin Wang* and Yongzhuo Huang*. Co-Delivery of Trichosanthin and Albendazole by Nano-Self- Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Appl Mater Interfaces, 2017, 9(32):26648-26664
28. Chun Zhang, Chengli Ling, Liang Pang, Qi Wang, Jingxin Liu, Bingshan Wang, Jianming Liang, Jing Qin*and Jianxin Wang*. Direct macromolecular drug to cerebral ischemia area using Neutrophil mediated nanoparticles. Theranostics, 2017,7(13):3260-3275
29. Ruixiang Li, Zhiqing Pang, Huining He, Seungjin Lee, Jing Qin, Jian Wu, Liang Pang, Jianxin Wang*and Victor C. Yang*. Drug depot-anchoring hydrogel: A self-assembling scaffold for localized drug release and enhanced stem cell differentiation. Journal of Controlled Release, 2017, 261:234-245
30. Cuitian Chen, Ziqing Duan, Ruixiang Li, Liang Pang, Yan Yuan, Jianming Liang, Xinchun Xu* and Jianxin Wang*. Peptide-22 and cyclic RGD functionalized liposomes for glioma targeting drug delivery overcoming BBB and BBTB. ACS Appl Mater Interfaces. 2017, 9:5864-5873
31. Jianyong Sheng, Huining He, Limei Han, Jing Qi, Sunhui Chen, Ge Ru, Ruixiang Li, Pei Yang, Jianxin Wang*and Victor C. Yang*. Enhancing Insulin Oral Absorption by Using Mucoadhesive Nanoparticles Loaded with LMWP-linked Insulin Conjugates. Journal of Controlled Release，2016,233:181-190
32. Jianyong Sheng, Limei Han, Jing Qin, Ge Ru, Ruixiang Li, Lihong Wu, Dongqi Cui, Pei Yang, Yuwei He, Jianxin Wang*. N-Trimethyl Chitosan Chloride-Coated PLGA Nanoparticles Overcoming Multiple Barriers to Oral Insulin Absorption. ACS Appl Mater Interfaces. 2015, (28) 7:15430-41
33. Huining He, Jianyong Sheng, Allan E David, Youngmin Kwon, Jian Zhang, Yongzhuo Huang, Jianxin Wang*, Victor C Yang*. The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption. Biomaterials, 2013, 34(31):7733-7743
34. Ming Shen, Yongzhuo Huang, Limei Han, Jing Qin, Xiaoling Fang, Jianxin Wang*, Victor C Yang*. Multifunctional drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release, 2012, 161:884-892
