杨萍

发布者:潘俊发布时间:2024-08-13浏览次数:39

姓名:杨萍

职称:正高级实验师

电子邮件:yangping@fudan.edu.cn

电话:021-50253028

学历:博士

 

个人简历

1990年兰州大学药学本科毕业, 2007年中国科学院兰州化理所博士毕业现为复旦大学药学院分析测试中心主任,正高级实验师

 

研究方向

主要从事现代仪器分析技术在药物筛选、药效评价的应用研究。包括:药物质量控制,质量标准建立,未知化合物结构鉴定、体内外药物分析、药动药代分析、基于质谱技术的代谢组、脂质组分析等等。参与国家自然基金面上项目4项,上海市基础研究重点项目1项,上海市创新行动计划1项。2009年主要参与基金项目:沪浦发改投2007133号,建设复旦和张江集团联合张江测试平台,并在2010-2012年负责该平台的管理工作。授权专利两项,申请专利三项。2012年度因表现突出荣获上海市大型仪器设施共享服务(技术类)先进个人。

  

代表性论著

1.Cao, Z. L., Zhou, W., Zhang, C. * and Yang, P*. (2023). Affinity Analysis of Recombinant Humanized Anti-VEGF Biosimilars with Fc Receptors. Bio-101 e1011004. Doi: 10.21769/BioProtoc.1011004

2. Zhonglian Cao, Hui Zhao, Jiajun Fan, Yilan Shen, Lei Han, Guangjun Jing, Xian Zeng, Xin Jin, Zeguo Zhu, Qi Bian,Yanyang Nan, Xiaozhi Hu, Xiaobin Mei*, Dianwen Ju*, Ping Yang*. Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response. Cell Death Discovery, 2023, 9:8

3.Qiao Zhang; Xiaomin Guo; Cao Xie; Zhonglian Cao; Xin Wang; Li Liu*; Ping Yang* ; Unravelingthe metabolic pathway of choline-TMA-TMAO: Effects of gypenosides and implications for the therapy of TMAO related diseases, Pharmacological Research, 2021, 173(173)

4.王昕,郭晓敏,程捷恺,刘莉,杨萍*, 基于UHPLC-Q-TOF-MS/MSLTQ-MSn联用技术快速鉴定绞股蓝皂苷类化学成分中国药学杂志,2020242044-2051

5. Xin Wang, Dan Li, Xiaomin Guo, Qiao Zhang, Xueling Liao, Zhonglian Cao, Li Liu*, Ping Yang*. ComMSnDB—An automatable strategy to identify compounds from MS data sets (identi-fication of gypenosides as an example). Journal of agriculture food and chemistry. 2020, 68(41):11368-11388

6. Peng Xu, Chen Xu, Xiaoxia Li, Dan Li, Yan Li, Jiebing Jiang, Ping Yang *, Gengli Duan *. Rapid Identification of Berberine Metabolites in Rat Plasma by UHPLC-Q-TOF-MS. Molecules. 2019,24,1994.

7.Zhihong Li, Xiaomin Guo, Zhonglian Cao, Xiujie Liu, Xueling Liao, Chao Huang,Wenqi Xu, Li Liu*, Ping Yang*. New MS network analysis pattern for the rapid identification of constituents from traditional Chinese medicine prescription Lishukang capsules in vitro and in vivo based on UHPLC/Q-TOF-MS. Talanta. 2018,189:606-621

8. 郭晓敏,程捷恺,张明,李丹,曹忠莲,杨萍*, UHPLC/MSn质谱树技术与Q/TOF联用在利舒康胶囊成分鉴定中的应用,中草药,2017101944-1956

9. Zhonglian Cao, Dan Li, Li Liu, Ping Yang*. Effect of Novel 5-Substituted Tetrandrine Derivatives on P-Glycoprotein-Mediated Inhibition and Transport in Caco-2 Cell, Oncology Letters. 2018,16: 6808-6814

10. Dan Li, zhonglian Cao, Xueling Liao, Ping Yang*, Li Liu*. The development of a quantitative and qualitative method based on UHPLC-QTOFMS/MS for evaluation paclitaxel–tetrandrine interaction and its application to a pharmacokinetic study, Talanta. 2016,160:256-267

11.Zhonglian Cao, Xiaoxia Li, Xueling Liao, Ping Yang*. Development of an HPLC-FLD Method for Determination of Rhodamine-123 in Caco-2 Cell-Based Permeability Studies, Chromatographia. 2016,79:261-266

12. Zhonglian Cao, Meredith Wright, Jiekai Cheng, Xiaoxing Huang, Li Liu, Lixing Wu, Ping Yang*, The novel bis-benzylisoquinoline PY35 reverses P-glycoprotein-mediated multidrug resistance, Oncology Reports 2014, 32(3): 1211-1217

13. 李蓓妤,朱依谆,杨萍* LC-MS法测定大蒜提取物中S-烯丙基-L-半胱氨酸的含量,复旦学报医学版 2010 371