董肖椿

董肖椿药物化学系,副教授,硕士生导师

教育经历

2004.9.-2007.6：复旦大学药学院药物化学专业，博士

2000.9.-2003.6：复旦大学药学院药物化学专业，硕士

1993.9.-1997.6：华东师范大学化学系化学专业，学士

工作经历

2013.12- 至今：复旦大学药学院药物化学教研室，副教授

2008.9 -2009.9：美国明尼苏达大学药学院药物化学系，博士后

1997.7- 2013.11：复旦大学药学院药物化学教研室，助教/讲师

承担科研项目情况

1. 上海市“科技创新行动计划”生物医药科技支撑专项项目（21S11907200），新型双阳离子硼修饰BODIPY抗菌光敏剂的临床前研究，主持

2. 上海市“科技创新行动计划”自然科学基金项目（21ZR1425600），新型小分子Myostatin通路抑制剂的设计、合成及其抗肿瘤恶病质作用研究，主持

3. 国家自然科学基金面上项目（21572037），新结构类型Hedgehog通路抑制剂的设计、合成和构效关系研究，主持

4. 上海市自然科学基金面上项目（12ZR1403300），含氮杂四元环骨架的新型Hedgehog通路抑制剂的设计、合成及抗肿瘤活性研究，主持

5. 国家自然科学基金面上项目（81573363），基于水淬灭近红外荧光探针的口服脂质纳米给药系统体内命运与作用机制研究，参与

6. 国家自然科学基金面上项目（81872816），新型水淬灭近红外荧光探针的设计及其在纳米粒体内过程研究中的应用，参与

研究方向

代表性论著

1. Chang Liu, Xin Ji, Zhiliang Yu, Shaohui Zhang, Rong Zhang, Weili Zhao, Xiaochun Dong*. Discovery of Subcellular-Targeted Aza-BODIPY Photosensitizers for Efficient Photodynamic Antitumor Therapy. J. Med. Chem., 2023, 66 (11): 7205-7220

2. Li Ruan, Junping Bai, Xin Ji, Weili Zhao, Xiaochun Dong*. A series of meso amide BODIPY based lysosome-targeting fluorescent probe with high photostability and sensitivity. Analytica Chimica Acta, 2022, 1205: 339771

3. Chang Liu, Yue Jin, Xin Ji, Weili Zhao*, Xiaochun Dong*. Access to Pyridinyl or Pyridinium Aza-BODIPYs with Tunable Near-Infrared Fluorescence through ICT from 4-Pyridinyl Pyrroles. Chem. Eur. J., 2022, e202201503

4. Shaohui Zhang, Xin Ji, Rong Zhang, Weili Zhao*, Xiaochun Dong*. Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications. Bioorg. Med. Chem. Lett., 2022, 73: 128910

5. Guangyu Lin, Mei Hu, Rong Zhang, Yuanxing Zhu, Kedan Gu, Junping Bai, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Discovery of Meso-(meta-Pyridinium) BODIPY Photosensitizers: In Vitro and In Vivo Evaluations for Antimicrobial Photodynamic Therapy. J. Med. Chem., 2021, 64 (24): 18143-18157

6. Zhiliang Yu, Junliang Zhou,Xin Ji, Guangyu Lin, Shuang Xu, Xiaochun Dong*, Weili Zhao*. Discovery of a Monoiodo Aza-BODIPY Near-Infrared Photosensitizer: in vitro and in vivo Evaluation for Photodynamic Therapy. J. Med. Chem., 2020, 63 (17): 9950-9964

7. Kedan Gu, Guangyu Lin, Yuanxing Zhu, Xin Ji, Jiyang Li*, Xiaochun Dong*, Weili Zhao*. Anchoring BODIPY photosensitizers enable pan-microbial photo-inactivation. Eur. J Med. Chem.,2020, 199: 112361

8. Zhifeng Xia, Yanyang Nan, Chang Liu, Guangyu Lin, Kedan Gu, Cheng Chen, Weili Zhao, Dianwen Ju, XiaochunDong*. Design, Synthesis and Biological Evaluation of Novel1,2,5-Oxadiazol-3-Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1(IDO1) Inhibitors. Anti-Cancer Agents in Medicinal Chemistry, 2020, 20: 1592-1603

9. Mingfei Zhu, Hong Wang, Chenglin Wang, Yanfen Fang, Tong Zhu, Weili Zhao, Xiaochun Dong*, Xiongwen Zhang*. L-4, a well-tolerated and orally active inhibitor of hedgehog pathway, exhibited potent anti-tumor effects against medulloblastoma in vitro and in vivo. Front. Pharmacol., 2019, 10, e89.

10. Xiaochun Dong, Chenglin Wang, Zhongjian Chen*, Weili Zhao*. Overcoming the Resistance mechanisms of Smoothened inhibitors, Drug Discovery Today,2018, 23: 704-710

11. Chenglin Wang, Mingfei Zhu,Xiuhong Lu, Hong Wang, Weili Zhao, Xiongwen Zhang*, Xiaochun Dong*. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors. Bioorg. Med. Chem., 2018, 26, 3308-3320

12. Xiuhong Lu, ZhongjianChen*, Xiaochun Dong*, Weili Zhao*. Water -Soluble Fluorescent Probe with Dual Mitochondria/Lysosome Targetability for Selective Superoxide Detection in Live Cells and in Zebrafish Embryos. ACS Sensors, 2018,3: 59-64

13. Xiuhong Lu, Yuanqiu Peng,Chenglin Wang, Jun Yang, Xiaolong Bao, Qian Dong, Weili Zhao*, WenfuTan*, Xiaochun Dong*. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors. Eur. J Med. Chem., 2017, 138, 384-395.